27 April 2022: Clinical Research
Differences Between Sorafenib and Lenvatinib Treatment from Genetic and Clinical Perspectives for Patients with Hepatocellular Carcinoma
Lei Wang 1CD* , Lei Wang 23DEF* , Bo Xiao 4BC , Mingxuan Cui 4CDE , Bo Zhang 4A*DOI: 10.12659/MSM.934936
Med Sci Monit 2022; 28:e934936
Figure 2 Establishment of protein–protein interaction (PPI) and miRNA-mRNA regulatory network. (A) The construction of PPI network, in which each dot represents a node. (B) The miRNA-mRNA regulatory network. The orange node is miRNA and the blue node is mRNA. The solid line represents positive regulation, and the dotted line represents negative regulation respectively. (C) The RT-PCR investigations of differentially expressed genes. (D) The RT-PCR investigations of differentially expressed miRNAs. (E) The expression levels of FGF4 for different treatments in Hep3B2.1–7 cells.