19 April 2023: Lab/In Vitro Research
Effects of the Dibenzofuran, Usnic Acid, on Inhibition of Ocular Biofilm Formation Due to Coagulase-Negative Staphylococci
Sertaç Argun Kıvanç 1ACDEF , Berna Akova 1ACDEF , Merih Kıvanç 2ABCDEF*DOI: 10.12659/MSM.940266
Med Sci Monit 2023; 29:e940266
Table 1 The antibiotic susceptibilities of coagulase-negative staphylococci that formed biofilm and minimum inhibitory concentration and minimum bactericidal concentration values of usnic acid.
| Bacteria | Biofilm | MIC (μg/ml) | MBC (μg/ml) | Antibiotics | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| CN10 | K30 | E15 | P10 | TE30 | ME5 | VA30 | MDR | ||||
| +++ | 62.5 | 500 | I | I | R | R | S | R | I | 3 | |
| +++ | 62.5 | – | S | S | I | R | S | S | R | 2 | |
| +++ | 62.5 | – | S | S | R | R | S | S | I | 2 | |
| +++ | 62.5 | – | S | S | R | R | S | S | S | 2 | |
| +++ | 62.5 | – | S | S | R | R | S | R | S | 3 | |
| +++ | – | – | S | S | R | R | S | S | I | 2 | |
| +++ | – | – | S | I | R | S | S | R | R | 3 | |
| +++ | – | – | S | I | R | R | S | S | S | 2 | |
| +++ | – | – | S | S | R | R | R | R | S | 4 | |
| +++ | – | 500 | S | R | S | R | S | S | S | 2 | |
| +++ | – | – | S | S | S | R | S | R | R | 3 | |
| +++ | – | – | I | R | R | R | R | R | S | 5 | |
| +++ | 31.2 | 500 | R | R | R | S | S | S | S | 3 | |
| +++ | – | – | S | S | R | R | S | R | S | 3 | |
| +++ | 62.5 | 500 | R | R | S | R | S | S | S | 3 | |
| +++ | – | – | R | R | S | R | S | R | S | 4 | |
| +++ | 62.5 | 500 | S | S | S | R | S | R | S | 2 | |
| +++ | – | – | S | S | S | R | S | R | S | 2 | |
| S. – ; MIC – minimum inhibitory concentration; MBC – minimum bactericidal concentration; CN – gentamicin; VA – vancomycin; K – kanamycin; E – erythromycin; P – penicillin; TE – tetracycline; ME – methicillin; I – intermediate; R – resistant; S – susceptible, μg – microgram; ml – milliliter; MDR – multi drug resistant. | |||||||||||