03 November 2022>: Database Analysis
Association Between Nadir Hematocrit and Severe Acute Kidney Injury After Off-Pump Coronary Artery Bypass Graft Surgery: A Retrospective Cohort Study Based on the MIMIC-IV Database
Yisen Deng 12ACE* , Bo Ma 2DE* , Xuming Wang 12DE* , Xueqiang Fan 2BC , Qiangqiang Nie 12B , Xixi Gao 2B , Yuguang Yang 2CE* , Peng Liu 12CE*DOI: 10.12659/MSM.937878
Med Sci Monit 2022; 28:e937878
Table 3 Subgroup analysis of the associations between hematocrit and severe acute kidney injury.
Subgroup | n | OR (95%CI) | P value | P for interaction |
---|---|---|---|---|
Age (y) | 0.305 | |||
1007.0 | 1 (0.87–1.15) | 0.981 | ||
≥70 | 776.0 | 0.85 (0.74–0.97) | 0.017 | |
Sex, n (%) | 0.644 | |||
Female | 384.0 | 0.15 (0.02–1.09) | 0.061 | |
Male | 1399.0 | 0.95 (0.85–1.05) | 0.295 | |
Race, n (%) | 0.325 | |||
White | 1249.0 | 0.96 (0.86–1.07) | 0.467 | |
Other | 534.0 | 0.85 (0.72–1) | 0.056 | |
BMI (kg/m) | 0.002 | |||
982.0 | 0.77 (0.64–0.92) | 0.005 | ||
≥30 | 801.0 | 0.97 (0.86–1.1) | 0.611 | |
Myocardial infarction | 0.908 | |||
No | 1073.0 | 0.9 (0.79–1.03) | 0.131 | |
Yes | 710.0 | 0.89 (0.78–1.02) | 0.097 | |
Congestive heart failure | 0.672 | |||
No | 1416.0 | 0.89 (0.78–1.01) | 0.075 | |
Yes | 367.0 | 0.95 (0.83–1.09) | 0.49 | |
Systolic BP (mm Hg) | 0.808 | |||
804.0 | 0.89 (0.8–1) | 0.056 | ||
≥110 | 979.0 | 0.95 (0.79–1.14) | 0.593 | |
Diastolic BP (mm Hg) | 0.124 | |||
1212.0 | 0.87 (0.78–0.96) | 0.007 | ||
≥60 | 571.0 | 0.99 (0.74–1.32) | 0.945 | |
Anion gap (mmol/L) | 0.778 | |||
797.0 | 0.89 (0.74–1.07) | 0.22 | ||
≥13 | 986.0 | 0.93 (0.83–1.04) | 0.187 | |
Sodium (mmol/L) | 0.196 | |||
652.0 | 0.8 (0.61–1.05) | 0.114 | ||
≥138 | 1131.0 | 0.94 (0.85–1.04) | 0.204 | |
Lactate (mmol/L) | 0.982 | |||
874.0 | 0.94 (0.79–1.12) | 0.491 | ||
≥2.6 | 909.0 | 0.93 (0.83–1.04) | 0.184 | |
Epinephrine use | 0.049 | |||
No | 1443.0 | 0.93 (0.82–1.06) | 0.304 | |
Yes | 340.0 | 0.88 (0.75–1.02) | 0.092 | |
Norepinephrine use | 0.398 | |||
No | 1503.0 | 0.9 (0.79–1.02) | 0.098 | |
Yes | 280.0 | 1 (0.85–1.16) | 0.949 | |
Phenylephrine use | 0.906 | |||
No | 713.0 | 0.95 (0.84–1.08) | 0.416 | |
Yes | 1070.0 | 0.9 (0.78–1.04) | 0.141 | |
SAPSII | 0.129 | |||
899.0 | 1.05 (0.82–1.34) | 0.711 | ||
≥36 | 884.0 | 0.89 (0.8–0.99) | 0.029 | |
AKI – severe acute kidney injury; BMI – body mass index; BP – blood pressure; SAPSII – simplified acute physiology score II. |