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19 September 2022: Clinical Research

Circulating Methylated DNA Analyses to Predict Recurrence Risk and Adjuvant Chemotherapy Benefit in Stage II to III Colorectal Cancer

Zhen Yuan 12ABCEF* , Shuyuan Wang 12ABCDEF* , Kemin Ni 12ACDF* , Yixiang Zhan 12ACDF* , Hong Ma 1BDF , Xinyu Liu 13ABC , Ran Xin 2ABC , Xingyu Zhou 2BC , Zhaoce Liu 12BC , Xuanzhu Zhao 14BC , Xin Yin 2BC , Hangyu Ping 2BC , Yaohong Liu 2BC , Wanting Wang 4BC , Suying Yan 4BC , Qiurong Han 4BC , Wei Cui 5CD , Xipeng Zhang 167ADF , Qinghuai Zhang 167ABCD* , Chunze Zhang 167ABCDEFG*

DOI: 10.12659/MSM.937757

Med Sci Monit 2022; 28:e937757

Supplementary Table 2 Relationship between postoperative mSETP9, CEA, CA19-9, and CA242 levels and recurrence status.

No recurrenceRecurrence
 Postoperative CEA elevated7/34 (20.6)5/19 (26.3)
 Postoperative CEA not elevated27/34 (79.4)14/19 (73.7)
 Postoperative CA19-9 elevated1/32 (3.1)4/19 (21.1)
 Postoperative CA19-9 not elevated31/32 (96.9)15/19 (78.9)
 Postoperative CA242 elevated2/25 (8)4/18 (22.2)
 Postoperative CA242 not elevated23/25 (90.2)14/18 (77.8)
 Postoperative CEA elevated27/230 (11.7)1/13 (7.7)
 Postoperative CEA not elevated203/230 (88.3)12/13 (92.3)
 Postoperative CA19-9 elevated15/220 (6.8)0/13 (0.0)
 Postoperative CA19-9 not elevated205/220 (93.2)13/13 (100.0)
 Postoperative CA242 elevated20/168 (11.9)1/12 (8.3)
 Postoperative CA242 not elevated148/168 (88.1)11/12 (91.7)
mSEPT9 – methylated setpin9.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750