05 September 2022: Clinical Research
Interaction of High-Sugar Diet and History of Stroke with Risk of Cognitive Decline in Older Adults
Qian Xu 1AEFG , Sicong Zhang 2BCD , Yanqing Gu 1C , Ping Wang 1D , Qian Zhang 1B , Chunlei Shan 234AEG*DOI: 10.12659/MSM.937572
Med Sci Monit 2022; 28:e937572
Table 4 Interaction between a history of stroke and high-sugar diet on cognitive decline.
| Content of added sugar | History of stroke | Model 1 | Model 2 | Model 3 | |||
|---|---|---|---|---|---|---|---|
| OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | ||
| Normal | No | Ref | Ref | Ref | |||
| Normal | Yes | 2.260 (1.375–3.714) | 1.749 (1.217–2.516) | 0.002 | 1.598 (1.010–2.529) | 0.037 | |
| High | No | 1.626 (1.256–2.104) | 1.691 (1.264–2.264) | 1.399 (1.005–1.946) | 0.038 | ||
| High | Yes | 5.110 (2.255–11.578) | 5.326 (2.236–12.685) | 3.254 (1.098–9.641) | 0.027 | ||
| RERI | 2.224 (−0.065–4.512) | 2.885 (−1.306–7.076) | 1.257 (0.188–2.326) | ||||
| API | 0.435 (0.146–0.724) | 0.542 (0.156–0.928) | 0.386 (0.135–0.638) | ||||
| SI | 2.179 (1.087–4.370) | 3.003 (1.001–9.006) | 2.261 (1.063–4.809) | ||||
| Unadjusted univariate logistic analysis; Multivariable logistic analysis adjusted for age, gender, diabetes and GHb; Multivariable logistic analysis adjusted for age, gender, diabetes, GHb, BMI, race, marital status, education, family income, drinking, vigorous work activity, vigorous recreational activities, depression disorder, hypertension, congestive heart failure, heart disease, TC and HDL. OR – odds ratio; CI – confidence interval; RERI – relative excess risk of interaction; SI – synergy index; API – attributable proportion of interaction. | |||||||