Alterations in Amygdala/Hippocampal Volume Ratios in Children with Obstructive Sleep Apnea Syndrome Caused by Adenotonsillar Hypertrophy

15 March 2023: Clinical Research

Yanshan Ma ^1ABCE* , Zheli Niu ^2ABCE* , Lin Ruan ^2CDF , Sisi Xue ^3CDF , Nan Li ^3F , Xiaoguang Yao ^3ABCE* , Qiang Li ^3AEFG*

DOI: 10.12659/MSM.937420

Med Sci Monit 2023; 29:e937420

Table 1 Demographic characteristics and clinical variables of subjects.

Category		ATH/OSA (n=100)	Controls (n=100)	P value
Age (y)	Mean (95% CI)	5. 74 (5.14, 6.35)	5.95 (5.35, 6.55)	0.57
BMI z score	Mean (95% CI)	0.37 (0.23, 0.52)	0.32 (0.19, 0.45)	0.57
Gender	Male/female	68/32	65/35	0.38
Smoking status in family	y/n	93/7	90/10	0.31
Asthma	y/n	5/95	0/100	0.024
Chronic or allergic rhinitis	y/n	14/86	0/100	0.000
Food/drug allergy	y/n	7/93	5/95	0.552
Eosinophil count (μL)		289.15±67.10	279.12±51.64	0.237
Total serum IgE (U/mL)		251.27±63.21	236.42±66.95	0.108
Amygdala volume	cm	2.65±0.21	2.17±0.18	0.000
Hippocampus volume	cm	7.08±0.11	7.29±0.15	0.000
A/H ratio		0.37±0.03	0.30±0.02	0.000
Tonsil hypertrophy
I°	N (%)	19 (19%)
II°	N (%)	68 (68%)
III°	N (%)	13 (13%)
Adenoid hypertrophy
I°	N (%)	5 (5%)
II°	N (%)	30 (30%)
III°	N (%)	58 (58%)
IV°	N (%)	7 (7%)
A/N ratio	Mean (95% CI)	0.85 (0.83, 0.86)	0.56 (0.55, 0.57)	0.000
Disease duration(months)	Mean (95% CI)	3.25 (2.96, 3.54)
Polysomnography variables
Mean SaO2	(%)	95.33±2.41
AHI		33.25±24.86
min Sao2	(%)	74.87±12.62
Percentage of SaO2	(%)	10.24±8.79
The data of the clinical variables and demographic characteristics are expressed as the mean±standard deviation (SD) for continuous variables when the data were normally distributed, as a 95% confidence interval (CI) when the data had a skewed distribution, or counts (percentages) for discrete variables.