21 April 2022: Database Analysis
Effect of Alzheimer Disease on Prognosis of Intensive Care Unit (ICU) Patients: A Propensity Score Matching Analysis
Baohua Zhu 1ABC , Xiaoli Chen 2CD , Wei Li 3DF , Dandan Zhou 3AEF*DOI: 10.12659/MSM.935397
Med Sci Monit 2022; 28:e935397
Table 1 Demographical characteristics and clinical basis data of the patients.
| Variables | All patients (n=33935) | Non-AD group (n=33502) | AD group (n=433) | P value |
|---|---|---|---|---|
| Demographics | ||||
| Age (y, Mean±SD) | 64.22±17.27 | 63.98±17.23 | 82.59±8.28 | 0.000* |
| Gender (% Male) | 19269 (56.78%) | 19087 (57%) | 182 (42%) | 0.000 |
| Weight (kg) | 81.05±23.86 | 81.21±23.9 | 68.66±16.31 | 0.000* |
| Comorbidity (%) | ||||
| Congestive heart failure | 4614 (13.6%) | 4524 (13.5%) | 90 (20.8%) | 0.000 |
| Valvular disease | 1651 (4.9%) | 1620 (4.8%) | 31 (7.2%) | 0.026 |
| Peripheral vascular | 2877 (8.5%) | 2846 (8.5%) | 31 (7.2%) | 0.321 |
| Hypertension | 3253 (9.6%) | 3194 (9.5%) | 59 (13.6%) | 0.004 |
| Chronic pulmonary | 6003 (17.7%) | 5937 (17.7%) | 66 (15.2%) | 0.179 |
| Diabetes | 8535 (36.6%) | 8428 (25.2%) | 107 (24.7%) | 0.832 |
| Hypothyroidism | 3196 (9.4%) | 3125 (9.3%) | 71 (16.4%) | 0.000 |
| Chronic kidney disease | 3902 (11.5%) | 3832 (11.4%) | 70 (16.2%) | 0.002 |
| Liver disease | 1964 (5.8%) | 1956 (5.8%) | 8 (1.8%) | 0.000 |
| Lymphoma | 419 (1.2%) | 414 (1.2%) | 5 (1.2%) | 0.879 |
| Tumor | 895 (2.6%) | 883 (2.6%) | 12 (2.8%) | 0.861 |
| Rheumatoid arthritis | 887 (2.6%) | 868 (2.6%) | 19 (4.4%) | 0.020 |
| Surgery | 10916 (32.2%) | 10845 (32.4%) | 71 (16.4%) | 0.000 |
| Treatment | ||||
| Vasopressor | 12753 (37.6%) | 12641 (37.7%) | 112 (25.9%) | 0.000 |
| RRT | 674 (1.99%) | 672 (2.0%) | 2 (0.5%) | 0.022 |
| Score | ||||
| SOFA | 4 (2, 6) | 4 (2, 6) | 4 (2, 6) | 0.003 |
| APS III | 39 (29, 52) | 39 (29, 52) | 45 (36.5, 59) | 0.000 |
| SAPS II | 33 (25, 43) | 33 (25, 43) | 42 (36, 50) | 0.000 |
| GCS | 14 (9, 15) | 14 (9, 15) | 11 (8, 14) | 0.000 |
| HR (bpm) | 85.07±18.4 | 85.1±18.41 | 82.54±17.5 | 0.663 |
| Data presented as n (%), mean±SD, or median and interquartile range (IQR). P values are comparisons between Alzheimer’s disease group with non-Alzheimer’s disease group. * Means uneven variance using F test. RRT – renal replacement therapy; SOFA – Sequential Organ Failure Assessment; APS III – Acute Physiology Score III; SAPS II – Simplified Acute Physiology Score II; GCS – Glasgow Coma Score; HR – heart rate. | ||||