13 February 2022>: Clinical Research
Gas Chromatography and Flame-Ionization Detection of Non-Cholesterol Sterols as Indicators of Cholesterol Absorption and Synthesis in 158 Chinese Individuals with Normolipidemia, Hyperlipidemia, and Familial Hypercholesterolemia
Zhi-Zhao Li 1DE* , Qi-Hui Wang 2C , Yang Liu 2C , Lv-Ya Wang 3A , Zhen-Qiu Yu 3A , Qiong Huang 4B , Jing Zhang 5BDOI: 10.12659/MSM.934471
Med Sci Monit 2022; 28:e934471
Table 5 Results of receiver operating characteristic curve for dyslipidemia group (n=69) and familial hypercholesterolemia group (n=25).
Item | AUC | SE | 95% CT | z | P | Youden Index | Associated criterion | Sensitivity (%) | Specificity (%) |
---|---|---|---|---|---|---|---|---|---|
Squalene | 0.883 | 0.035 | 0.799–0.940 | 1.386 | 0.588 | ≤0.76 | 100.00 | 58.82 | |
Desmosterol | 0.956 | 0.027 | 0.892–0.988 | 16.618 | 0.851 | >0.24 | 88.00 | 97.06 | |
Lathosterol | 0.822 | 0.051 | 0.729–0.893 | 6.352 | 0.554 | ≤1.23 | 76.00 | 79.41 | |
Campesterol | 0.581 | 0.065 | 0.475–0.683 | 1.249 | 0.212 | 0.205 | ≤0.86 | 44.00 | 76.47 |
Stigmasterol | 0.640 | 0.076 | 0.534–0.737 | 1.853 | 0.064 | 0.337 | ≤0.19 | 44.00 | 89.71 |
Sitosterol | 0.746 | 0.059 | 0.645–0.831 | 4.184 | 0.499 | ≤1.53 | 72.00 | 77.94 | |
Model 3 | 1.000 | 0.961–1.000 | – | 1.000 | >−14.51 | 100.00 | 100.00 | ||
Model 3: squalene+desmosterol+lathosterol+campesterol+stigmasterol+sitosterol. AUC – area under the ROC curve; SE – standard error; TC – total cholesterol; TG – triglycerides. |