15 December 2020>: Clinical Research
Measurement of Cyclin D2 () Gene Promoter Methylation in Plasma and Peripheral Blood Mononuclear Cells and Alpha-Fetoprotein Levels in Patients with Hepatitis B Virus-Associated Hepatocellular Carcinoma
Yu Qian 1ABCDEF , Jing-Wen Wang 1BC , Yu-Fang 1BCD , Xiao-Dong Yuan 1B , Yu-Chen Fan 12ADF , Shuai Gao 12CDFG , Kai Wang 12ADEG*DOI: 10.12659/MSM.927444
Med Sci Monit 2020; 26:e927444
Table 1 Characterization of the study participants.
Variable | HCC group (n=118) | LC group (n=47) | CHB group (n=75) | HC group (n=35) |
---|---|---|---|---|
Age (years) | 54 (49–62) | 52 (42–60) | 50 (40–57) | 47 (39–55) |
Male gender, n (%) | 87 (73.73) | 35 (74.47) | 52 (69.33) | 23 (65.71) |
HBeAg+, n (%) | 43 (36.44) | 22 (46.81) | 41 (54.67) | NA |
ALT (U/L) | 37.50 (24.00–69.50) | 51.00 (30.00–98.00) | 101.00 (57.00–227.00) | NA |
AST (U/L) | 46.00 (30.75–99.25) | 62.00 (36.00–121.00) | 61.00 (42.00–121.00) | NA |
TBIL (μmol/L) | 18.35 (13.93–37.93) | 22.50 (15.40–46.40) | 20.00 (11.80–49.90) | NA |
ALB (g/L) | 39.90 (33.98–43.13) | 40.80 (34.90–44.60) | 41.60 (37.50–44.90) | NA |
PT-INR | 1.10 (1.02–1.20) | 1.12 (1.05–1.21) | 1.11 (1.05–1.21) | NA |
AFP (ng/mL) | 36.41 (4.98–317.78) | 12.90 (9.18–115.20) | 15.91 (6.21–77.98) | NA |
Methylation in PBMCs/plasma, n (%) | 55 (46.61)/52 (44.07) | 8 (17.02)/5 (10.64) | 8 (10.67)/7 (9.33) | 4 (11.43)/2 (5.71) |
HCC – hepatocellular carcinoma; LC – liver cirrhosis; CHB – chronic hepatitis B; HCs – healthy controls; ALT – alanine aminotransferase; AST – aspartate aminotransferase; TBIL – total bilirubin; ALB – albumin; PT-INR – prothrombin time-international normalized ratio; AFP – alpha-fetoprotein; PBMCs – peripheral blood mononuclear cells; NA – not available. |