29 April 2008
Melatonin: adjuvant therapy of malignant tumors
Piotr Dziegiel, Marzena Podhorska-Okolow, Maciej ZabelMed Sci Monit 2008; 14(5): RA64-70 :: ID: 855743
Abstract
This review summarizes the most relevant data relating to the potential role of melatonin (pineal secretory product) as an adjuvant therapy of tumors. Results of clinical studies were preceded by a description of experiments conducted on tumor cell lines and on laboratory animals. Most of the reports unequivocally confirmed the antioxidative and immunostimulatory action of the pineal secretory product in both in vitro and in vivo experiments. Results of studies on cell lines of various tumors showed that the anti-proliferative effect of melatonin might involve a receptor-mediated mechanism. In experiments on animals, the cardio-, nephro-, and myelo-protective action of melatonin was confirmed in the course of application of various cytostatic drugs. A meta-analysis of clinical studies in which melatonin was applied as an adjuvant drug in the therapy of various tumors pointed to some effects of its administration. Therefore, the use of melatonin could offer hope in future antitumor therapy.
Keywords: Models, Biological, Melatonin - therapeutic use, Immune System, Hormones - metabolism, Combined Modality Therapy - methods, Chemotherapy, Adjuvant - methods, Neoplasms - pathology, Antioxidants - metabolism, Antineoplastic Agents - therapeutic use
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
07 Mar 2024 : Clinical Research
Knowledge of and Attitudes Toward Clinical Trials: A Questionnaire-Based Study of 179 Male Third- and Fourt...Med Sci Monit In Press; DOI: 10.12659/MSM.943468
08 Mar 2024 : Animal Research
Modification of Experimental Model of Necrotizing Enterocolitis (NEC) in Rat Pups by Single Exposure to Hyp...Med Sci Monit In Press; DOI: 10.12659/MSM.943443
18 Apr 2024 : Clinical Research
Comparative Analysis of Open and Closed Sphincterotomy for the Treatment of Chronic Anal Fissure: Safety an...Med Sci Monit In Press; DOI: 10.12659/MSM.944127
08 Mar 2024 : Laboratory Research
Evaluation of Retentive Strength of 50 Endodontically-Treated Single-Rooted Mandibular Second Premolars Res...Med Sci Monit In Press; DOI: 10.12659/MSM.944110
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952