02 September 1996
Assessment of fusafungine efficacy and tolerance in upper respiratory infections
Bolesław Samoliński, Janusz Kamiński, Marcin KargulMed Sci Monit 1996; 2(5): PI650-656 :: ID: 500092
Abstract
Assessment of clinical efficacy of fusafungine, a preparation combining properties of antibiotic and antiinflammatory agents, was carried out on a group of 1325 patients with symptoms of acute inflammation of the nasal mucosa, sinuses, pharynx, palatine tonsils and bronchi. Patients were subjected to a seven-day treatment and evaluation. Fusafungine effects on particular symptoms and clinical efficacy were assessed by both patients and their physicians in charge. The study was done as an open multicentre trial. In 35% of patients antiinflammatory nonsteroid drugs were administered; 18% of patients received general antibiotics (50% of those were given in bronchitis). Statistically significant differences in remission were noted in the majority of conditions as early as the first 24 hours (p<0.01). The best results were observed in acute palatine tonsillitis (except for streptococcal pharyngitis) and acute rhinitis and pharyngitis (very good and good results represented by 92% and 93% respectively). In bronchitis and sinusitis the effects were milder (77% and 78% respectively). Sore throat, hoarseness and nasal congestion showed the most effective (over 40%) and quickest (50% symptom reduction at 4 days) remission. The poorest results were observed in remission of cough and rhinorrhoea (less than 35% improvement, 50% symptom reduction as late as at 7 days). In general the best results were noted in 39%, good in 48% and poor in 13% of the patients. A poor response was observed in 4% of cases. Adverse symptoms were reported by 8% of patients and proved to be local.
Keywords: Sinusitis, Pharyngitis, Laryngitis, Bronchitis, antibiotic therapy, fusafungine
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
07 Mar 2024 : Clinical Research
Knowledge of and Attitudes Toward Clinical Trials: A Questionnaire-Based Study of 179 Male Third- and Fourt...Med Sci Monit In Press; DOI: 10.12659/MSM.943468
08 Mar 2024 : Animal Research
Modification of Experimental Model of Necrotizing Enterocolitis (NEC) in Rat Pups by Single Exposure to Hyp...Med Sci Monit In Press; DOI: 10.12659/MSM.943443
18 Apr 2024 : Clinical Research
Comparative Analysis of Open and Closed Sphincterotomy for the Treatment of Chronic Anal Fissure: Safety an...Med Sci Monit In Press; DOI: 10.12659/MSM.944127
08 Mar 2024 : Laboratory Research
Evaluation of Retentive Strength of 50 Endodontically-Treated Single-Rooted Mandibular Second Premolars Res...Med Sci Monit In Press; DOI: 10.12659/MSM.944110
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952