20 December 2020>: Animal Study
Effect of Asthma on Erectile Dysfunction in Rats as Determined by Biological Network Analysis
Jisheng Wang 12ABCDEF* , Xuefeng Gong 3ABCDEF* , Sheng Deng 12ABCDEF* , Fanchao Meng 12CDE , Hengheng Dai 12DEF , Binghao Bao 12CD , Junlong Feng 12BF , Haisong Li 2AFG* , Bin Wang 2AFG*DOI: 10.12659/MSM.927491
Med Sci Monit 2020; 26:e927491
Figure 1 Study flow chart. On the basis of the DAVID database, we predicted the proteins and pathways associated with asthma and erectile dysfunction (ED). We used real-time quantitative polymerase chain reaction and western blotting to measure expression of insulin, albumin, vascular endothelial growth factor A, tumor necrosis factor, and interleukin 6 proteins and messenger ribonucleic acid in rat penis cells of each group. The results of in vivo experiments were consistent with the prediction results of bioinformatics analysis. Asthma can induce systemic inflammation and extensive vascular endothelial damage, which then leads to ED.