Figure 1 (A) Volcano plot of all differentially expressed genes (DEGs) identified among the 14 tyrosine kinase inhibitor (TKI)-resistant transplanted tumor samples and 14 untreated controls. (B) Lasso coefficient profiles of the fractions of 32 DEGs. (C) Tenfold cross-validation for tuning parameter selection in the Lasso model. (D) Correlations between the expression levels of 6 specific genes associated with clear cell renal cell carcinoma (ccRCC) were determined with the Spearman correlation coefficient. (E) Six DEGs that were highly related to the survival of ccRCC patients were identified by univariate Cox regression analysis.