11 November 2022>: Review Articles
Autophagy and Its Association with Genetic Mutations in Parkinson Disease
Nour S. Erekat EF*DOI: 10.12659/MSM.938519
Med Sci Monit 2022; 28:e938519
Table 1 Future developments in gene-based treatment of Parkinson disease.
Target | Drug | Mechanism of action | References |
---|---|---|---|
α-synuclein | Antisense oligonuleotides | Reducing α-synuclein expression in animals | []134 |
NPT200-11 | Inhibiting α-synuclein misfolding | []136 | |
Nilotinib | Augmenting the autophagic elimination of α-synuclein | [,]135 | |
Prasinuzemab | Passive immunotherapy against α-synuclein | []139 | |
PD03A | Active immunotherapy against α-synuclein | []140 | |
LRRK2 | DNL201 | Selective inhibition of LRRK2 kinase | []142 |
Antisense oligonuleotides | Suppressing the overall kinase activity of LRRK2 | []143 | |
GCase | PR001A | Augmenting GCase activity using gene therapy | []149 |
Ambroxol | Increasing GCase activity | []144 | |
LRRK2 – leucine-rich repeat kinase 2; GCase – β-glucocerebrosidase. |