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22 September 2022: Clinical Research

Impact of Adherence with Disease-Modifying Therapies on All-Cause Mortality Rates Among Veterans with Multiple Sclerosis

Meheroz H. Rabadi 12ABCDEF* , Kimberly Just 1B , Chao Xu 3CDE

DOI: 10.12659/MSM.938116

Med Sci Monit 2022; 28:e938116

Table 1 Demographics based on multiple sclerosis survival (dichotomized).

Alive (n=223)Dead (n=56)p-value
Mean (SD)49.3 (12.2)61.9 (10.0)
Mean (SD)21.4 (12.3)34.6 (13.3)
34 (15.4%)1 (1.9%)
 ≥10 and ≤1973 (33.0%)5 (9.2%)
 ≥20114 (51.6%)48 (88.9%)
Mean (SD)8.15 (3.57)12.2 (3.36)
 Relapsing remitting107 (48.9%)8 (15.1%)
 Progressive (primary and secondary)78 (35.6%)42 (79.2%)
 Other (CIS RIS)30 (13.7%)1 (1.9%)
 Unclassified category4 (1.8%)2 (3.8%)
Mean (SD)27.5 (3.13)25.6 (8.04)0.104
Mean (SD)3.57 (2.81)6.73 (2.18)
 0–3120 (55.8%)3 (7.1%)
 3.5–649 (22.8%)8 (19.1%)
 >646 (21.4%)31 (73.8%)
Mean (SD)110 (21.1)81.4 (29.6)
102 (48.6%)38 (70.4%)0.006
30 (14.2%)19 (35.2%)0.001
Mean (SD)28.4 (5.27)25.7 (7.49)0.018
(yes)142 (64.8%)33 (60.0%)0.532
(yes)142 (66.4%)35 (81.4%)0.07
 Infusion17 (7.6%)1 (1.8%)
 Injectables41 (18.4%)5 (8.9%)
 Never/none/other99 (44.4%)50 (89.3%)
 Oral66 (29.6%)0 (0%)
DMT – disease modifying therapies; MS – multiple sclerosis; MMSE – Mini-Mental State Examination; TFIM – Total Functional Independence Measure; EDSS – Expanded Disability Scale Score.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750