25 July 2022>: Database Analysis
Integrating Network Pharmacology, Molecular Docking, and Experimental Validation to Investigate the Mechanism of (−)-Guaiol Against Lung Adenocarcinoma
Yaoying Zeng 1E* , Yanbin Pan 1B* , Bo Zhang 1C , Yingbin Luo 1D , Jianhui Tian 1AF , Yuli Wang 1CD , Xudong Ju 2BF , Jianchun Wu 1A* , Yan Li 1A*DOI: 10.12659/MSM.937131
Med Sci Monit 2022; 28:e937131
Supplementary Table 1 The identified genes of DEGs, WGCNA module genes, and drug target genes.
DEGs | ADAMTS1 | AKAP12 |
A2M | ADAMTS8 | AKR1B10 |
AADAC | ADAMTSL4 | AKR1C2 |
AATK | ADGRE5 | ALDH18A1 |
ABCA3 | ADGRF5 | ALDH1A1 |
ABCA8 | ADGRL2 | ALDH2 |
ABCC3 | ADH1B | ALDH3B1 |
ABCG1 | ADPRH | ALDOA |
ABHD11 | ADRB1 | ALG1L |
ABI3BP | ADRB2 | ALOX15 |
AC007906.2 | AFAP1L1 | ALOX15B |
ACADL | AGER | ALOX5 |
ACE | AGR2 | ALOX5AP |
ACKR1 | AGR3 | ALPL |
ACP5 | AGRP | AMOTL1 |
ACVRL1 | AGTR2 | ANGPT1 |
ADA2 | AHNAK | ANKRD1 |
ADAM8 | AK1 | ANKRD22 |
ANKRD29 | BZW2 | CCL23 |
ANLN | C11orf96 | CCL24 |
ANOS1 | C14orf132 | CCM2L |
ANXA3 | C15orf48 | CCN1 |
AOC1 | C16orf89 | CCN2 |
AOC3 | C1orf115 | CCN5 |
APLN | C1orf116 | CCNA2 |
APOBR | C1orf162 | CCNB1 |
APOC1 | C1orf194 | CCNB2 |
APOL3 | C1orf198 | CCND2 |
APOLD1 | C1QA | CCT3 |
AQP1 | C1QB | CCT5 |
AQP4 | C1QC | CD101 |
AQP9 | C2 | CD163 |
ARHGAP18 | C20orf85 | CD24 |
ARHGAP31 | C4BPA | CD300C |
ARHGAP44 | C5AR1 | CD300LF |
ARHGEF15 | C5orf38 | CD300LG |
ARHGEF26 | C7 | CD34 |
ARHGEF6 | C8B | CD36 |
ARRB1 | C9orf24 | CD44 |
ASF1B | CA2 | CD52 |
ATF3 | CA4 | CD53 |
ATIC | CA9 | CD74 |
ATOH8 | CACNA2D2 | CD79A |
ATP13A4 | CADM1 | CD83 |
AURKA | CALCOCO1 | CD93 |
AURKB | CALCRL | CDC20 |
B3GNT3 | CAMK2N1 | CDCA5 |
B3GNT6 | CASKIN2 | CDCA7 |
BASP1 | CAT | CDCA8 |
BCHE | CAV1 | CDH3 |
BCL2A1 | CAV2 | CDH5 |
BCL6B | CAVIN1 | CDK1 |
BEX4 | CAVIN2 | CDKN2B |
BIRC5 | CBLC | CDO1 |
BMP2 | CBX7 | CEACAM1 |
BMPR2 | CCBE1 | CEACAM5 |
BOP1 | CCDC167 | CELF2 |
BPIFA1 | CCDC69 | CENPF |
BTG2 | CCL18 | CEP55 |
BTNL9 | CCL21 | CES1 |
CFD | CTHRC1 | ECRG4 |
CGNL1 | CTNNAL1 | ECSCR |
CHI3L2 | CTSH | ECT2 |
CHRDL1 | CTSS | EDN1 |
CITED2 | CX3CL1 | EDNRB |
CKS1B | CXCL12 | EEF1A2 |
CLDN18 | CXCL13 | EFCC1 |
CLDN3 | CXCL14 | EFEMP1 |
CLDN5 | CXCL16 | EFNA4 |
CLEC14A | CXCL2 | EFNB2 |
CLEC3B | CYB5A | EGFL7 |
CLIC3 | CYBB | EGLN3 |
CLIC5 | CYBRD1 | EGR1 |
CNN1 | CYP24A1 | EGR2 |
COL10A1 | CYP27A1 | EHD2 |
COL11A1 | CYP4B1 | EIF4EBP1 |
COL17A1 | CYYR1 | EMCN |
COL1A1 | DAPK1 | EMP1 |
COL1A2 | DCN | EMP2 |
COL3A1 | DENND3 | EMP3 |
COL5A1 | DEPP1 | ENG |
COL5A2 | DERL3 | ENO1 |
COL6A6 | DES | EPAS1 |
COLEC12 | DHCR24 | EPCAM |
COMP | DKK3 | EPHX3 |
COX4I2 | DLC1 | ERG |
COX7A1 | DLGAP5 | ERO1A |
CP | DMBT1 | ESAM |
CPA3 | DNAJC12 | ETS1 |
CPAMD8 | DNASE1L3 | ETV4 |
CPB2 | DNTTIP1 | EVI2B |
CRABP2 | DOK2 | FABP4 |
CRIM1 | DPEP2 | FABP5 |
CRLF1 | DPT | FAM107A |
CRTAC1 | DPYSL2 | FAM162B |
CRYAB | DRAM1 | FAM167A |
CSF3 | DSG2 | FAM183A |
CSF3R | DSP | FAM189A2 |
CSRNP1 | DUOX1 | FAM216B |
CST1 | DUOXA1 | FAM83A |
CSTA | DUSP1 | FBLN1 |
CT83 | DUSP4 | FBLN5 |
FBP1 | GATA2 | HBEGF |
FBXO32 | GATA6 | HCAR2 |
FCER1G | GBP4 | HCK |
FCGR3A | GCNT3 | HEG1 |
FCN1 | GDF10 | HES6 |
FCN3 | GGCT | HHIP |
FEN1 | GGTLC1 | HIGD1B |
FERMT1 | GIMAP1 | HJURP |
FERMT2 | GIMAP4 | HK3 |
FGB | GIMAP6 | HLA-DOA |
FGD5 | GIMAP7 | HLA-DPA1 |
FGFBP2 | GIMAP8 | HLA-DPB1 |
FGFR2 | GJA1 | HLA-DQA1 |
FGFR4 | GJA4 | HLA-DQB1 |
FGL1 | GJA5 | HLA-DRA |
FGR | GJB2 | HLA-DRB1 |
FHL1 | GKN2 | HLA-DRB5 |
FHL2 | GLIPR2 | HLA-E |
FHL5 | GMFG | HLF |
FIBIN | GNAQ | HMGA1 |
FKBP10 | GNG11 | HMGB3 |
FKBP11 | GOLM1 | HPGD |
FLI1 | GPA33 | HS6ST2 |
FLRT3 | GPC3 | HSD17B6 |
FMO2 | GPD1 | HSPA12B |
FOLR1 | GPIHBP1 | HSPB6 |
FOS | GPM6A | HSPB8 |
FOSB | GPM6B | HSPD1 |
FOXF1 | GPRC5A | HSPE1 |
FOXM1 | GPRIN2 | HYAL1 |
FPR1 | GPT2 | HYAL2 |
FPR2 | GPX2 | ID1 |
FUT2 | GPX3 | ID3 |
FUT3 | GRAMD2A | ID4 |
FXYD6 | GRASP | IFT57 |
FZD4 | GRK5 | IGFBP3 |
GABARAPL1 | GYPC | IGLL5 |
GADD45B | H1-0 | IL1RL1 |
GALNT18 | H1-2 | IL33 |
GALNT7 | H2BC5 | IL3RA |
GAPDH | HBA2 | IL6 |
GAS6 | HBB | IL7R |
INAVA | KLF6 | LTBP4 |
INMT | KLF9 | LY86 |
IQANK1 | KPNA2 | LYVE1 |
IQGAP3 | KRT4 | LYZ |
IRAK1 | KRT6A | MAL |
IRX2 | KRT8 | MAMDC2 |
ITGA8 | KRT80 | MANF |
ITGB4 | KRTCAP3 | MAOA |
ITIH5 | LAD1 | MAOB |
ITLN1 | LAMA3 | MARCKSL1 |
ITLN2 | LAMP3 | MARCO |
ITM2A | LAPTM4B | MATN3 |
ITPKA | LAPTM5 | MCEMP1 |
ITPRID2 | LARGE2 | MCM2 |
ITPRIP | LBH | MCM4 |
JAM2 | LCN2 | MDK |
JAML | LCP1 | MELK |
JCAD | LDB2 | METTL7A |
JPT1 | LDHA | METTL7B |
JUN | LDLR | MEX3A |
JUNB | LEPR | MFAP4 |
JUND | LGALSL | MFNG |
KANK2 | LGI3 | MFSD2A |
KANK3 | LGR4 | MGAT3 |
KAT2A | LHFPL6 | MGP |
KCNJ15 | LIFR | MID1IP1 |
KCNJ8 | LILRA5 | MKI67 |
KCNK3 | LIMCH1 | MME |
KCNN4 | LIMS2 | MMP1 |
KCTD12 | LIPA | MMP11 |
KDELR3 | LMCD1 | MMP12 |
KIAA0040 | LMNB1 | MMP13 |
KIAA1324L | LMO2 | MMP19 |
KIF11 | LMO7 | MMP28 |
KIF1C | LMOD1 | MMP9 |
KIF20A | LPL | MMRN1 |
KIF2C | LRRC32 | MMRN2 |
KIF4A | LRRC36 | MNDA |
KIFC1 | LRRK2 | MRC1 |
KLF13 | LRRN4 | MROH6 |
KLF2 | LSR | MS4A15 |
KLF4 | LST1 | MS4A4A |
MS4A7 | NOTCH4 | PGC |
MS4A8 | NPM3 | PGGHG |
MSMO1 | NPNT | PHACTR1 |
MSR1 | NPR1 | PHLDA2 |
MSRB3 | NQO1 | PI16 |
MT1A | NR4A1 | PID1 |
MT1M | NR4A3 | PIGR |
MTARC2 | NRGN | PILRA |
MTHFD2 | NRN1 | PIP5K1B |
MT-ND6 | NTN4 | PKIG |
MTURN | NUSAP1 | PKP3 |
MUC13 | OCIAD2 | PLA2G1B |
MUC20 | OGN | PLA2G4A |
MUC21 | OLFML1 | PLA2G4F |
MUC5B | OLR1 | PLAC8 |
MYADM | OSCAR | PLAC9 |
MYBL2 | OTUD1 | PLAU |
MYCT1 | OTULINL | PLBD1 |
MYH10 | P3H2 | PLEK2 |
MYH11 | P3H4 | PLEKHO2 |
MYL9 | P4HB | PLK1 |
MYRF | P53 | PLLP |
MYZAP | PAEP | PLOD2 |
MZB1 | PAFAH1B3 | PLPP2 |
NAPSA | PAICS | PLPP3 |
NCF2 | PAPSS2 | PLSCR4 |
NCKAP5 | PCDH12 | PMP22 |
NDNF | PCOLCE2 | PNPLA6 |
NDRG2 | PCP4 | PODXL2 |
NDST1 | PCSK9 | POSTN |
NEBL | PCYOX1 | PPARG |
NECAB1 | PDGFB | PPBP |
NECTIN4 | PDIA4 | PPP1R14A |
NEDD9 | PDK4 | PPP1R14B |
NEK2 | PDLIM1 | PPP1R14D |
NES | PDLIM2 | PPP1R15A |
NET1 | PDPN | PRAM1 |
NFIX | PDZD2 | PRC1 |
NHSL1 | PEBP4 | PRDX4 |
NKG7 | PECAM1 | PRELP |
NME1 | PER1 | PRF1 |
NME4 | PFKP | PRG4 |
PROM2 | ROBO4 | SERPING1 |
PROS1 | RPL39L | SERTM1 |
PRX | RRAD | SESN1 |
PSAT1 | RRAS | SEZ6L2 |
PSMG3 | RRM2 | SFN |
PTGDS | RTKN2 | SFTPA1 |
PTGER4 | S100A2 | SFTPA2 |
PTGES | S100A3 | SFTPB |
PTGIS | S100A4 | SFTPC |
PTPN21 | S100A8 | SFTPD |
PTPRB | S100P | SGCA |
PTPRM | S1PR1 | SGCE |
PTTG1 | S1PR4 | SGK1 |
PXDC1 | SAMHD1 | SGPP2 |
PYCR1 | SAPCD2 | SH2D3C |
QKI | SASH1 | SHMT2 |
QPCT | SBK1 | SHROOM4 |
RAB11FIP1 | SCARA5 | SIRPA |
RAC3 | SCD | SIRPB1 |
RAI2 | SCD5 | SLC11A1 |
RAMP1 | SCEL | SLC15A2 |
RAMP2 | SCGB1A1 | SLC15A3 |
RAMP3 | SCGB3A1 | SLC19A3 |
RARRES2 | SCGB3A2 | SLC1A1 |
RASGRF1 | SCN4B | SLC25A10 |
RASIP1 | SCN7A | SLC25A25 |
RASL12 | SCNN1B | SLC25A39 |
RBMS2 | SCUBE1 | SLC27A3 |
RBP4 | SDC2 | SLC2A1 |
RCAN1 | SEC14L6 | SLC2A3 |
RCC1 | SECISBP2L | SLC34A2 |
RCN3 | SELENBP1 | SLC35F2 |
RECQL4 | SELENOP | SLC39A8 |
RETN | SELP | SLC46A2 |
RGCC | SELPLG | SLC50A1 |
RGS5 | SEMA3B | SLC52A2 |
RHOJ | SEMA3G | SLC6A4 |
RHOV | SEMA4B | SLC7A5 |
RIPOR1 | SEMA5A | SLC7A7 |
RMI2 | SERINC1 | SLCO2A1 |
RNASE1 | SERINC2 | SLCO2B1 |
RNF144B | SERPINA1 | SLIT2 |
SLIT3 | STXBP6 | TMPRSS4 |
SLPI | SULF1 | TNFRSF21 |
SMAD6 | SUSD2 | TNFSF12 |
SMIM22 | SVEP1 | TNFSF13 |
SMPDL3B | SYNPO | TNNC1 |
SNX25 | SYT7 | TNNT1 |
SOCS2 | TACC1 | TNS1 |
SOCS3 | TBC1D2 | TNS2 |
SOD3 | TBX2 | TNS3 |
SORBS3 | TBX3 | TNXB |
SOSTDC1 | TBX4 | TOM1L2 |
SOX17 | TCF21 | TOP2A |
SOX4 | TCN1 | TPPP |
SOX7 | TEK | TPPP3 |
SPAG4 | TENT5B | TPSAB1 |
SPAG5 | TESC | TPSB2 |
SPARCL1 | TFF1 | TPX2 |
SPDEF | TFPI2 | TRAF4 |
SPI1 | TFRC | TREM1 |
SPINK1 | TGFBR2 | TRIP13 |
SPN | TGFBR3 | TRPV2 |
SPOCK2 | THBD | TSC22D3 |
SPP1 | THBS2 | TSKU |
SPTBN1 | THSD1 | TSPAN12 |
SPTBN2 | THY1 | TSPAN18 |
SRD5A3 | TIE1 | TSPAN7 |
SRGN | TIMP1 | TSTA3 |
SRPK1 | TIMP3 | TTYH3 |
SRPX | TK1 | TUBA1A |
SRPX2 | TLCD1 | TUBB6 |
SSR4 | TLR4 | TXNDC17 |
ST14 | TMEM100 | TXNIP |
ST6GALNAC1 | TMEM125 | TYMS |
ST6GALNAC5 | TMEM132A | TYROBP |
ST6GALNAC6 | TMEM139 | UBE2C |
STAC | TMEM184A | UBE2T |
STARD13 | TMEM190 | UBL3 |
STARD8 | TMEM204 | UCHL1 |
STEAP1 | TMEM45B | UGDH |
STK39 | TMEM47 | UNC5CL |
STOM | TMEM88 | UPK3B |
STX11 | TMPRSS11E | UTRN |
VAMP2 | VSIG4 | WNT3A |
VCAN | VSIR | WWC2 |
VEGFD | VSTM2L | XPR1 |
VEPH1 | VWF | ZBED2 |
VIM | WASF3 | ZDHHC9 |
VIPR1 | WFDC2 | ZFP36 |
VMP1 | WFS1 | ZNF385B |
VSIG2 | WIF1 | ZWINT |