BACKGROUND: The X-ray cross-complementing group 3 (XRCC3) gene encodes a protein that plays an important role in homologous recombination repair (HRR) of DNA double-strand break (DSB). Increasing attention has been drawn to the association of XRCC3 T241M polymorphism with various types of human cancers. In this study, a meta-analysis was performed to investigate whether there is an association between XRCC3 T241M polymorphism and thyroid cancer risk.

MATERIAL AND METHODS: A comprehensive search was conducted and a total of 8 studies that covered 963 thyroid cancer cases and 1942 controls were included in this analysis. The meta-analysis was performed on both overall database and 2 ethnic subgroups (Caucasian and Asian). The fixed-effects model was used to calculate odds ratio (OR) with 95% confidence intervals (CIs). The publication bias was evaluated using Begg’s funnel plots and Egger’s test.

RESULTS: A positive association between XRCC3 T241M polymorphism and thyroid cancer risk was found by the analyses of the overall database using both recessive model (OR=1.40, 95% CI=1.08–1.81, P=0.012) and homozygote comparison (OR=1.41, 95% CI=1.07–1.86, P=0.015), but not by that using the dominant model (OR=1.12, 95% CI=0.95–1.33, P=0.18). However, no significant association of XRCC3 Thr241Met polymorphism with the risk of thyroid cancer was found in individual ethnic subgroups.

CONCLUSIONS: We conclude that the XRCC3 Thr241Met polymorphism is associated with an increased risk of thyroid cancer in the overall population, while no significant association was observed in individual ethnic subgroups due to limited population size.

Keywords: DNA-Binding Proteins - genetics, Amplified Fragment Length Polymorphism Analysis, Genetic Predisposition to Disease, Methionine - genetics, Threonine - genetics, Thyroid Neoplasms - genetics