28 April 2010
Effect of the osmolality of caloric and acaloric liquids on gastric myoelectrical activity in humans
Danuta Syrkiewicz-TrepiakBCDEF, Krzysztof JonderkoACDEFG, Anna Kasicka-JonderkoCDEFMed Sci Monit 2010; 16(5): CR252-259 :: ID: 878546
Abstract
Background
The aim was to establish the effect of the osmolality of orally consumed liquids on gastric myoelectrical activity (GMA).
Material and Method
Twenty-five healthy volunteers (13 women, 12 men aged 29.4+/-1.4 [SE] years) underwent five examinations on separate days. After a 20-min basal electrogastrographic recording, the volunteers drank 400 ml of a) bi-distilled water, b) 0.9% NaCl, osmolality 286 mmol/kg, c) 2.9% NaCl, osmolality 827 mmol/kg, d) 5% glucose, osmolality 282 mmol/kg, energy density 209 kcal/l, or e) 15% glucose, osmolality 836 mmol/kg, 627 kcal/l. Then the registration of GMA was continued for 60 min. Gastric emptying was measured with the 13C-acetate breath test.
Results
Compared with distilled water, the isotonic glucose drink elicited a positive chronotropic influence on and stabilization of GMA. At the transition from isotonicity to hypertonicity, a pronounced destabilization of GMA was observed, with opposite directions of changes brought about by the presence or absence of a caloric load; bradygastria was manifested after the energy-free hypertonic NaCl solution whereas hypertonic glucose evoked a tachygastric pattern. A marked delay in gastric emptying was found with both hypertonic drinks.
Conclusions
Osmolality and its interplay with chemical composition/energy density must be taken into account when choosing a test meal for an electrogastrographic examination and interpreting its results. Of the five fluids examined, isotonic glucose appeared to be the drink least disturbing to GMA.
Keywords: Osmolar Concentration, Gastric Emptying, Single-Blind Method, Energy Intake, Stomach - physiology
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
06 Mar 2024 : Clinical Research
Comparison of Outcomes between Single-Level and Double-Level Corpectomy in Thoracolumbar Reconstruction: A ...Med Sci Monit In Press; DOI: 10.12659/MSM.943797
21 Mar 2024 : Meta-Analysis
Economic Evaluation of COVID-19 Screening Tests and Surveillance Strategies in Low-Income, Middle-Income, a...Med Sci Monit In Press; DOI: 10.12659/MSM.943863
10 Apr 2024 : Clinical Research
Predicting Acute Cardiovascular Complications in COVID-19: Insights from a Specialized Cardiac Referral Dep...Med Sci Monit In Press; DOI: 10.12659/MSM.942612
06 Mar 2024 : Clinical Research
Enhanced Surgical Outcomes of Popliteal Cyst Excision: A Retrospective Study Comparing Arthroscopic Debride...Med Sci Monit In Press; DOI: 10.12659/MSM.941102
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952