21 December 2009
Statins and beta-cell function
Lei QianAEFG, Lihong XuDF, Yi LinAD, Yongde PengEGMed Sci Monit 2010; 16(1): HY1-2 :: ID: 878299
Abstract
Statins, as 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitors, have long been known for having significant effects on plasma lipid and lipoprotein profiles, lowering total and LDL cholesterol and raising HDL-C level. Many studies have previously found that statin therapy reduced the risk of occlusive vascular events in people with diabetes mellitus. In fact, type 2 diabetes is often accompanied by abnormal blood lipid and lipoprotein levels, but most studies on the link between hyperlipidemia and pathogenesis of diabetes have focused on free fatty acids (FFAs), which were believed to enhance hyperglycemia- induced beta cell deterioration and insulin secretion impairment, while the impact of cholesterol in the pathogenesis of diabetes has not been reported. Although the relationship between elevated cholesterol and diabetes has not been extensively examined, there is some evidence supporting a potential link between the two. Firstly, lipoprotein level is closely correlated with the concentration of plasma cholesterol, and the former is a good predictor for onset of diabetes. Secondly, a few clinical studies have indicated that use of statins can delay the progression of diabetes. Though the mechanism underlying this phenomenon is still elusive, it was recently found that elevated serum cholesterol can impair insulin secretion and increase the rate of apoptosis in beta cells, which may offer a promising clue to how statins work.
Keywords: Insulin - secretion, Insulin-Secreting Cells - secretion, Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology, Diabetes Mellitus, Type 2 - prevention & control, Cholesterol - blood, Lipoproteins - blood
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
05 Mar 2024 : Clinical Research
Effects of Thermal Insulation on Recovery and Comfort of Patients Undergoing Holmium Laser LithotripsyMed Sci Monit In Press; DOI: 10.12659/MSM.942836
05 Mar 2024 : Clinical Research
Role of Critical Shoulder Angle in Degenerative Type Rotator Cuff Tears: A Turkish Cohort StudyMed Sci Monit In Press; DOI: 10.12659/MSM.943703
06 Mar 2024 : Clinical Research
Comparison of Outcomes between Single-Level and Double-Level Corpectomy in Thoracolumbar Reconstruction: A ...Med Sci Monit In Press; DOI: 10.12659/MSM.943797
21 Mar 2024 : Meta-Analysis
Economic Evaluation of COVID-19 Screening Tests and Surveillance Strategies in Low-Income, Middle-Income, a...Med Sci Monit In Press; DOI: 10.12659/MSM.943863
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952