Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

Correlation between left ventricular mass and the resting and post-exercise release of ANP in healthy men

Lucjan Pawlicki, Robert Irzmański, Stanisław Różalski, Jan Kowalski, Franciszek Kokot

Med Sci Monit 2001; 7(5): CR903-907 :: ID: 508613

Abstract

Background: The goal of our study was to assess the impact of left ventricular mass on the resting and post-exercise release of atrial natriuretic peptide (ANP) in healthy young men.
Material/Methods: The study involved 36 young men divided into two groups. Group I consisted of 18 healthy untrained men 20-24 years old (mean 22.1). Group II included 18 healthy men aged 22-27 years (mean 23.4 years) who had been taking regular dynamic and static physical exercise for at least 2 years. Echocardiograms were performed in both groups. The thickness of the posterior wall (PW-d), the thickness of the interventricular septum (IV-d), and the left ventricular end-diastole dimension (DdLV) were measured and used to calculate the left ventricular mass. Subsequently, all the patients underwent an exercise test on a cycloergometer. The workload in both groups was 2 Watts/kg at 60 rpm. The anticipated age-adjusted heart rate values at this workload were 170/min in Group I and 155/min in Group II. Blood samples were collected before the exercise test and 1 minute afterwards. The concentrations of ANP and sodium ions and the hematocrit index were measured.
Results: In Group I the mean left ventricular mass was 193.1&plusm;51.8 g; in Group II, 248.1&plusm;91.91 g, which is a statistically significant difference. The resting ANP concentration in Group I was higher than in Group II (24.44&plusm;12.35 pg/ml vs 21.39&plusm;11.03 pg/ml), but the difference was not statistically significant. After exercise there was a significant increase in ANP concentration in both groups: 53.89&plusm;39.98 pg/ml and 47.50&plusm;26.67 pg/ml respectively. There was no correlation between the ANP concentration before and after exercise and the left ventricular mass in either group. There were also no differences between the two groups in resting hematocrit: 48% in Group I and 49.5% in Group II. A significant increase in hematocrit was observed in both groups after exercise. Exertion induced a significant decrease in the plasma sodium concentration in both groups. The ratio of mean plasma ANP concentration at rest to left ventricular mass, corrected according to hematocrit values, was 6.10 in Group I and 4.25 in Group II; after exercise, 14.06 and 9.72 respectively. The ratio of post-exercise increase in ANP concentration to left ventricular mass was 7.6 in Group I and 5.32 in Group II. The average left ventricular mass in Group II, although 30% greater than in Group I, did not exceed 259 g, which is considered the upper limit of normal. Despite this difference the ANP concentration in Group II was ca. 20% lower than in Group II, without cardiac hypertrophy. In both groups a significant increase in ANP concentration was observed when the subjects were exposed to submaximal workload. In Group II, however, the increase was markedly lower. No correlation was found between left ventricular mass at rest and post-exercise ANP release, nor between left ventricular mass and ANP secretion. By contrast, a tendency towards lower ANP release was found in Group II, despite the markedly larger left ventricular mass.
Conclusions: In the evaluation of risk related to left ventricular hypertrophy, both the mass index and cardiac functional efficiency should be taken into account.

Keywords: atrial natriuretic peptide (ANP), Exercise, left ventricular hypertrophy, Exercise Test

Add Comment 0 Comments

Editorial

01 March 2024 : Editorial  

Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-Thalassemia

Dinah V. Parums

DOI: 10.12659/MSM.944204

Med Sci Monit 2024; 30:e944204

0:00

In Press

18 Mar 2024 : Clinical Research  

Sexual Dysfunction in Women After Tibial Fracture: A Retrospective Comparative Study

Med Sci Monit In Press; DOI: 10.12659/MSM.944136  

0:00

21 Feb 2024 : Clinical Research  

Potential Value of HSP90α in Prognosis of Triple-Negative Breast Cancer

Med Sci Monit In Press; DOI: 10.12659/MSM.943049  

22 Feb 2024 : Review article  

Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943168  

23 Feb 2024 : Clinical Research  

A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943732  

Most Viewed Current Articles

16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750