Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

Association of lipid metabolism with subclinical diabetic cardiomyopathy in children and adolescents with type 1diabetes

Bożena Florys, Mirosława Urban, Barbara Głowińska

Med Sci Monit 2000; 6(2): CR342-347 :: ID: 508484

Abstract

Nowadays, it is known that atherosclerosis is not a disease affecting elderly people but that it starts as early as in childhood. Children with diabetes mellitus are particularly prone to early development of atherosclerosis. It seems advisable to evaluate the behaviour of lipoprotein (a), apolipoprotein B (atherogenic factors), and apolipoprotein A-I in this group of patients as possible causal or preventive factors of the developing diabetic cardiomyopathy. The purpose of this study was to evaluate the effect of the intensification of lipid metabolism disorders on systolic-diastolic parameters of heart ventricles in children and adolescents with insulin-dependent diabetes mellitus. The study was performed on 19 children and adolescents (11 boys and 8 girls) at the age of 8.4-18.5 (x=14.2) who have had insulin-dependent diabetes mellitus for 1.5 to 14 years (x=7.9 years). Control group consisted of 17 healthy children. All patients were subjected to full echocardiographic examination which measured the systolic-diastolic activity of both heart ventricles, and to examinations determining the presence of complications (including the subclinical ones). Additionally, patients had their lipid metabolism parameters defined, i.e.: Lp(a), apo A-I, apo B, triglycerides, cholesterol and its LDL and HDL fractions. Conclusions: 1. Children and adolescents with type 1 diabetes mellitus have higher concentration of Lp(a) and apolipoprotein B irrespective of the degree of diabetes control, which makes them prone to premature development of atherosclerosis.2. Lipid metabolism disorders do not have direct influence on the development of diabetic cardiomyopathy in young patients with type 1 diabetes mellitus.
key words: diabetic cardiomyopathy, type 1 diabetes, lipoprotein(a)

Keywords: Lipoprotein(a), Type 1 diabetes, diabetic cardiomyopathy

Add Comment 0 Comments

Editorial

01 March 2024 : Editorial  

Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-Thalassemia

Dinah V. Parums

DOI: 10.12659/MSM.944204

Med Sci Monit 2024; 30:e944204

0:00

In Press

18 Mar 2024 : Clinical Research  

Sexual Dysfunction in Women After Tibial Fracture: A Retrospective Comparative Study

Med Sci Monit In Press; DOI: 10.12659/MSM.944136  

0:00

21 Feb 2024 : Clinical Research  

Potential Value of HSP90α in Prognosis of Triple-Negative Breast Cancer

Med Sci Monit In Press; DOI: 10.12659/MSM.943049  

22 Feb 2024 : Review article  

Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943168  

23 Feb 2024 : Clinical Research  

A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943732  

Most Viewed Current Articles

16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750