01 January 1999
Serum cytokines concentrations in patients with infective endocarditis. A possible role in diagnosis and monitoring
Irena Rawczyńska-Englert, Tomasz Hryniewiecki, Danuta DzierżanowskaMed Sci Monit 1999; 5(1): CR89-92 :: ID: 505260
Abstract
Introduction: Early diagnosis of infective endocarditis is important for the clinical outcome since mortality increases with a longer diagnostic delay. The diagnosis of infective endocarditis is mainly based on clinical features, echocardiography and blood culture findings. Unfortunately negative blood cultures have been reported in up to 30% of proved cases. The aim of the study was to investigate usefulness of serum cytokines concentrations in diagnosis and monitoring of infective endocarditis.
Material and Method: The study group consisted of 30 patients with acquired rheumatic valvular heart diseases and ongoing infective endocarditis. The diagnosis of infective endocarditis was established on clinical examination, echocardiography, laboratory investigations (inflammatory parameters) and positive blood cultures (in 26 patients). Control group consisted of 10 patients with acquired rheumatic valvular heart diseases without infective endocarditis. Serum interleukin-1a (IL-1a), interleukin-6 (IL-6) and a tumor necrosis factor-a (TNF-a) concentrations were measured three times during antimicrobial treatment (mean interval 16±8 days).
Results: Serum IL-1a and TNF-a concentrations were not elevated in any patient or control (IL-1a<3.9 pg/ml, TNF-a<10 pg/ml - below calibration range). Serum IL-6 concentrations were elevated in all measuring points in patients with infective endocarditis (first: 36.7±48.1, second: 19.2±17.5 third: 8.7±5.7 pg/ml) with a significant tendency to decrease during treatment (ANOVA, p<0.01). In all controls serum IL-6 concentrations were below calibration range (<3.2 pg/ml).
Conclusions: 1. Elevated serum IL-6 concentrations may suggest ongoing infective endocarditis and could be an additional parameter in diagnosis and monitoring treatment of the disease. 2. Serum IL-1a and TNF-a concentrations were not affected. Further understanding the role of serum cytokines concentrations in diagnosing, prognosis and monitoring of infective endocarditis could be useful in clinically uncertain diagnosis especially while blood cultures are negative.
Keywords: Cytokines, infective endocarditis, Diagnosis
Editorial
01 March 2024 : Editorial
Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-ThalassemiaDOI: 10.12659/MSM.944204
Med Sci Monit 2024; 30:e944204
In Press
18 Mar 2024 : Clinical Research
Sexual Dysfunction in Women After Tibial Fracture: A Retrospective Comparative StudyMed Sci Monit In Press; DOI: 10.12659/MSM.944136
21 Feb 2024 : Clinical Research
Potential Value of HSP90α in Prognosis of Triple-Negative Breast CancerMed Sci Monit In Press; DOI: 10.12659/MSM.943049
22 Feb 2024 : Review article
Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...Med Sci Monit In Press; DOI: 10.12659/MSM.943168
23 Feb 2024 : Clinical Research
A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...Med Sci Monit In Press; DOI: 10.12659/MSM.943732
Most Viewed Current Articles
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952