01 January 1999
Blood fructosamine levels in patients with primary and metastatic brain tumors
Barbara Chmielewska, Ewa Belniak-Legieć, Zbigniew StelmasiakMed Sci Monit 1999; 5(1): CR58-61 :: ID: 505219
Abstract
Hyperglikemia increases the blood protein glycosylated reaction. Central nervous system (CNS) organic diseases may change the systemic metabolism. The aim of this study was to evaluate blood glycosylated protein levels (fructosamine - FA) in patients with CNS tumors. Patients were divided into two groups: those with a primary brain tumor (n=12, mean age - 58 years) and those with a metastatic brain tumor (n=12, mean age - 57.9), without diabetes or cachexy. Their protein, albumin and glucose levels were within normal values. We determined FA levels by means of the frustosamine reductive method in relation to nitrotetrazoline blue, using the Boehringer Mannheim GmbH Diagnostica set. p < 0.02 was considered as statistically significant, evaluated by means of the Mann-Whitney U test. The control group comprised 11 patients (mean age - 63.7 years). We noted an increase in fructosamine levels in patients with CNS tumors. A statistically significant difference was observed in patients with metastatic tumors, in comparison with controls (287.8 µmol/l vs. 214.9 µmol/l). An elevation in FA levels was evidence of increased glycosylation, in CNS tumor patients, due to an increase of mean glucose values in the past 2-4 weeks.
Keywords: primary brain tumors, serum fructosamine level, adults
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
06 Mar 2024 : Clinical Research
Prevalence and Variation of Medical Comorbidities in Oral Surgery Patients: A Retrospective Study at Jazan ...Med Sci Monit In Press; DOI: 10.12659/MSM.943884
08 Mar 2024 : Clinical Research
Evaluation of Foot Structure in Preschool Children Based on Body MassMed Sci Monit In Press; DOI: 10.12659/MSM.943765
15 Apr 2024 : Laboratory Research
The Role of Copper-Induced M2 Macrophage Polarization in Protecting Cartilage Matrix in OsteoarthritisMed Sci Monit In Press; DOI: 10.12659/MSM.943738
07 Mar 2024 : Clinical Research
Knowledge of and Attitudes Toward Clinical Trials: A Questionnaire-Based Study of 179 Male Third- and Fourt...Med Sci Monit In Press; DOI: 10.12659/MSM.943468
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952