Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

Adverse reactions to interferon alpha (INF alpha) treatment in children with chronic viral hepatitis

Anna Szaflarska-Szczepanik, Ewa Łoś, Andrzej Chrobot, Kinga Michalska, Mieczysława Czerwionka-Szaflarska

Med Sci Monit 1999; 5(5): CR878-884 :: ID: 503346

Abstract

The aim of the study was to evaluate adverse reactions to the treatment with interferon alpha in children with chronic hepatitis B and/or C. 162 children, both boys and girls aged 1-16 years, who completed the treatment with interferon were included in our analysis. Adverse reactions were compared in relation to the type of hepatotropic virus, patient's age, gender and concomitant diseases. We also analysed whether there was any correlation with the kind of medicinal product used INFa (or Roferon).The study revealed that different adverse reactions following interferon-therapy occurred in 84% children. The most common included: higher body temperature, lack of appetite, osteoarticular and muscular pain and anaemia. There were no significant differences in the occurrence of these reactions in relation to virus type and patients' gender. On the other hand, slight differences were observed in children from various age groups and between those treated with various interferon preparations. Side effects (autoimmune complications, convulsions) required the discontinuation of therapy only in 4 children (2.5%).Summing up, children with chronic hepatitis B and/or C treated with interferon a frequently display adverse reactions, but in the majority of cases these side effects are of mild intensity and allow for the continuation of treatment.

Keywords: children, chronic viral hepatitis, interferon alpha

Add Comment 0 Comments

Editorial

01 March 2024 : Editorial  

Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-Thalassemia

Dinah V. Parums

DOI: 10.12659/MSM.944204

Med Sci Monit 2024; 30:e944204

0:00

In Press

18 Mar 2024 : Clinical Research  

Sexual Dysfunction in Women After Tibial Fracture: A Retrospective Comparative Study

Med Sci Monit In Press; DOI: 10.12659/MSM.944136  

0:00

21 Feb 2024 : Clinical Research  

Potential Value of HSP90α in Prognosis of Triple-Negative Breast Cancer

Med Sci Monit In Press; DOI: 10.12659/MSM.943049  

22 Feb 2024 : Review article  

Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943168  

23 Feb 2024 : Clinical Research  

A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943732  

Most Viewed Current Articles

16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750