01 January 1998
A pilot trial of cladribine (2-chlorodeoxyadenosine) in remitting-elapsing multiple sclerosis
Zbigniew Stelmasiak, Janusz Solski, Jacek Nowicki, Ewa Porębska-Piwowarczyk, Mirosław S. Ryba, Pawel GriebMed Sci Monit 1998; 4(1): BR4-8 :: ID: 502798
Abstract
Lymphocytotoxic nucleoside analog cladribine (2-chlorodeoxyadenosine) has recently been reported to favourably alter the clinical course of chronic progressive multiple sclerosis (MS). In the present study 10 patients with the remitting-relapsing form of MS were treated with six courses of this drug (5 mg subcutaneously or 10 mg orally, once daily, repeated on five consecutive days) given once a month, followed by two additional courses at three month intervals. The patients were observed for two years after the initiation of the therapy. The treatment resulted in the reduction of lymphocyte counts to approx. 40% of the initial value at 6 months, with a trend toward recovery evident only at 24 months. Neurological status of the patients (expressed semiquantitatively according to the EDSS scale) showed a significant improvement between 6 and 15 month of the study. The number of relapses, compared to the two-year period immediately before the treatment, remained unchanged in three patients, and was markedly reduced (almost five times on average) in the remaining seven patients. Patients who experienced the reduced relapse rate also seemed to show longer and more pronounced improvement in their neurological status.
Keywords: Multiple Sclerosis, cladribine, Immunosuppression
Editorial
01 March 2024 : Editorial
Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-ThalassemiaDOI: 10.12659/MSM.944204
Med Sci Monit 2024; 30:e944204
In Press
21 Feb 2024 : Clinical Research
Potential Value of HSP90α in Prognosis of Triple-Negative Breast CancerMed Sci Monit In Press; DOI: 10.12659/MSM.943049
22 Feb 2024 : Review article
Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...Med Sci Monit In Press; DOI: 10.12659/MSM.943168
23 Feb 2024 : Clinical Research
A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...Med Sci Monit In Press; DOI: 10.12659/MSM.943732
26 Feb 2024 : Clinical Research
Predictive Value of Combined HbA1c and Neutrophil-to-Lymphocyte Ratio for Diabetic Peripheral Neuropathy in...Med Sci Monit In Press; DOI: 10.12659/MSM.942509
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952