02 March 1998
Reduction of glycated hemoglobin levels by long term, high dose ascorbic acid supplementation in healthy and diabetic patients
Erika Szaleczky, József Prechl, Eva Ruzicska, Janos Feher, Laszlo Braun, Gabor Banhegyi, Miklos Csala, József Mandl, Aniko SomogyiMed Sci Monit 1998; 4(2): CR241-244 :: ID: 502573
Abstract
The effect of long term, high dose ascorbic acid supplementation on blood glucose concentration levels was investigated upon in 17 healthy and 19 diabetic patients measuring their glycated hemoglobin (HbA1c) levels. Ascorbic acid treatment resulted in a significant reduction in HbA1c (7 and 9% of initial values in control and diabetic groups, respectively). The extent of the reduction was dependent on initial glycated hemoglobin levels in both groups, therefore, the effect of ascorbic acid was more pronounced in the diabetic group. Ascorbic acid supplementation elevated the plasma levels of reduced glutathione by 81 and 108 %. in control and diabetic groups, respectively. It is suggested that the increase of serum antioxidant glutathione and the decrease of glycated hemoglobin after long term ascorbic acid supplementation are related to each other.
Keywords: diabetes, glycation, Ascorbic Acid, Glucose, ascorbate
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
06 Mar 2024 : Clinical Research
Prevalence and Variation of Medical Comorbidities in Oral Surgery Patients: A Retrospective Study at Jazan ...Med Sci Monit In Press; DOI: 10.12659/MSM.943884
08 Mar 2024 : Clinical Research
Evaluation of Foot Structure in Preschool Children Based on Body MassMed Sci Monit In Press; DOI: 10.12659/MSM.943765
15 Apr 2024 : Laboratory Research
The Role of Copper-Induced M2 Macrophage Polarization in Protecting Cartilage Matrix in OsteoarthritisMed Sci Monit In Press; DOI: 10.12659/MSM.943738
07 Mar 2024 : Clinical Research
Knowledge of and Attitudes Toward Clinical Trials: A Questionnaire-Based Study of 179 Male Third- and Fourt...Med Sci Monit In Press; DOI: 10.12659/MSM.943468
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952