01 July 1997
Myocardial infarction in women. Part II - analysis of long-term survival and prognostic factors during 2-year follow-up
Zbigniew Religa, Maria Krzemińska-Pakuła, Zbigniew Bednarkiewicz, Dorota SkirzyńskaMed Sci Monit 1997; 3(4): CR524-529 :: ID: 501359
Abstract
The aim of the study was to analyse the outcome of women after first acute myocardial infarction (MI) compared to men during 2-year follow-up. The main end-points: cardiac death, rate of reinfarction and recurrent angina were evaluated and the percentage of coronary angiography, PTCA and surgical revascularisation were analysed. Study population consisted of 83 women (mean age 58.1 years) admitted to the Cardiological Department of the Medical Academy in ü-d with a diagnosed first MI. Patients were divided into subgroups according to their age. The control group was formed of 235 men hospitalised in the Clinic during the same period. During follow-up all patients underwent several diagnostic procedures including: physical examination, ECG, 24-hour Holter monitoring and two-dimensional echocardiography. First examination (B0) was performed before discharge (14.7 day after acute MI), second (B1) at 6th month, third (B2) at 12th month and the last one (B3) at 24th month. In each control visit clinical status according to NYHA classification, left ventricular ejection fraction (EF), ventricular rhythm disturbances (Lown classification), presence of painful/painless myocardial ischaemia during Holter monitoring were assessed. Chi squared and Fisher tests were used for the assessment of the correlation between all variables (p.<0.05). For multivariate analysis the logistic regression model was calculated. During two-year follow-up 13 cardiac deaths occurred in womenOs group (15.6%) compared to 25 (10.6%) in men - p.<0.01. The rate of reinfarction was also significantly higher in women (32.1% vs 18.4%) and especially in older ones. Retrospectively, most indices of cardiac instability (85.3 recurrences of angina, 81.2% of reinfarction and 61.5% of cardiac deaths) occurred within the first 12 months after the acute phase of MI. The main predictors of poor prognosis after MI were: severe ventricular arrhythmia (III Lown class or more), cardiac failure (III-IV NYHA class), poor left ventricular function (EF<40%), painful and mixed ischaemia detected by Holter monitoring and age above 56 years. As in the first part of the study sex was an independent factor of increased risk of cardiac complications in women after the first acute MI.
Keywords: Coronary Artery Disease, Women, acute myocardial infarction, long-term prognosis
Editorial
01 March 2024 : Editorial
Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-ThalassemiaDOI: 10.12659/MSM.944204
Med Sci Monit 2024; 30:e944204
In Press
21 Feb 2024 : Clinical Research
Potential Value of HSP90α in Prognosis of Triple-Negative Breast CancerMed Sci Monit In Press; DOI: 10.12659/MSM.943049
22 Feb 2024 : Review article
Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...Med Sci Monit In Press; DOI: 10.12659/MSM.943168
23 Feb 2024 : Clinical Research
A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...Med Sci Monit In Press; DOI: 10.12659/MSM.943732
26 Feb 2024 : Clinical Research
Predictive Value of Combined HbA1c and Neutrophil-to-Lymphocyte Ratio for Diabetic Peripheral Neuropathy in...Med Sci Monit In Press; DOI: 10.12659/MSM.942509
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952