Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

03 March 1997

Estimation of early toxicity induced by cytostatic agents used in the chemotherapy of childhood neoplasms

Danuta Kurylak, Andrzej Kurylak, Mariusz Wysocki, Anna Balcar-Boroń

Med Sci Monit 1997; 3(2): PI266-273 :: ID: 500725

Abstract

In the study we examined the incidence of adverse effects and their severity expressed on the WHO scale as well as of early toxicity induced by cytostatic agents used in the chemotherapy of 109 children with neoplasms treated in the years 1988-1993. The incidents of myelosuppression and related neutropenia and infections predominated in that group of patients. Compared to earlier periods the incidence of toxic complications involving the liver, gasto-intestinal mucasa and kidneys increased. Other adverse effects occurred only occasionally, but not infrequently they were life-threatening. Ara-C was responsible for the most incidents of severe symptoms of myelosuppression and vomiting, while hepatoxicity and toxic damage to the gastro-intesinal mucosa was mostly due to MTX. Symptoms of allergy were the most frequently observed following the treatment with L-aspa and MTX. The incidence of toxic central nervous system complications was the same after Ara-C, CY, ACTD and VCR. Occasional pancreatic complications could be related to the treatment with L-aspa. The cytostatics which caused the significantly most severe complications according to the WHO scale were Ara-C, MTX, VCR, CY and ADM.

Keywords: cytostatic agents, toxicity, childhood neoplasms

Add Comment 0 Comments

Editorial

01 March 2024 : Editorial  

Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-Thalassemia

Dinah V. Parums

DOI: 10.12659/MSM.944204

Med Sci Monit 2024; 30:e944204

0:00

In Press

21 Feb 2024 : Clinical Research  

Potential Value of HSP90α in Prognosis of Triple-Negative Breast Cancer

Med Sci Monit In Press; DOI: 10.12659/MSM.943049  

22 Feb 2024 : Review article  

Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943168  

23 Feb 2024 : Clinical Research  

A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943732  

26 Feb 2024 : Clinical Research  

Predictive Value of Combined HbA1c and Neutrophil-to-Lymphocyte Ratio for Diabetic Peripheral Neuropathy in...

Med Sci Monit In Press; DOI: 10.12659/MSM.942509  

Most Viewed Current Articles

17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750