30 January 2007
Expression of alpha6 integrin subunit is associated with malignancy in gastric gastrointestinal stromal tumors.
Hiromitsu Takeyama, Hitoshi Funahashi, Hirozumi Sawai, Hiroki Takahashi, Minoru Yamamoto, Yoshimi Akamo, Tadao ManabeMed Sci Monit 2007; 13(2): CR51-56 :: ID: 473726
Abstract
BACKGROUND: Gastrointestinal stromal tumors (GISTs) are the most common non-epithelial neoplasms of the gastrointestinal tract. The aim of this study was to investigate the clinicopathological and immunohistochemical features of gastric GISTs and to evaluate the degree of integrin expression in order to determine the need for surgery or predict the prognosis for GIST patients. MATERIAL/METHODS: Clinicopathological findings were obtained from patients' records. Specimens from 32 cases of gastric GIST were analyzed with immunohistochemical methods. The c-kit negative examples among the original 48 patients with gastric submucosal and muscle layer tumors were excluded from the study. RESULTS: There was a significant correlation between p53 protein expression and tumor malignancy. The positive staining for proliferating cell nuclear antigen was observed in all patients, and the mean tumor proliferation index for benign and malignant groups were 3.0% and 16.3%, respectively. alpha5beta1 integrin and alpha6 integrin subunit were expressed from moderately to strongly in tumor cells, and alpha 6 integrin subunit expression correlated significantly with whether tumors were classified as benign or malignant. However, there were no significant differences between the survival of GIST patients and integrin expression, mitotic rate, tumor size, or tumor malignancy. CONCLUSIONS: Malignant GISTs show significant expression of alpha6 integrin subunit. It may be useful in supporting other parameters, such as p53, MI, and tumor size. We suggest that alpha6 integrin subunit expression may be useful as an indication for surgery and also as one of several prognostic factors.
Keywords: Aged, 80 and over, Gastrointestinal Stromal Tumors - surgery, Integrin alpha6 - metabolism, Stomach Neoplasms - surgery, Tumor Suppressor Protein p53 - metabolism
Editorial
01 March 2024 : Editorial
Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-ThalassemiaDOI: 10.12659/MSM.944204
Med Sci Monit 2024; 30:e944204
In Press
18 Mar 2024 : Clinical Research
Sexual Dysfunction in Women After Tibial Fracture: A Retrospective Comparative StudyMed Sci Monit In Press; DOI: 10.12659/MSM.944136
21 Feb 2024 : Clinical Research
Potential Value of HSP90α in Prognosis of Triple-Negative Breast CancerMed Sci Monit In Press; DOI: 10.12659/MSM.943049
22 Feb 2024 : Review article
Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...Med Sci Monit In Press; DOI: 10.12659/MSM.943168
23 Feb 2024 : Clinical Research
A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...Med Sci Monit In Press; DOI: 10.12659/MSM.943732
Most Viewed Current Articles
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952