01 January 2002
Course of viral hepatitis B and combined B and C hepatitis in children treated for neoplastic diseases.
Robert Debski, Jan Styczyński, Mariusz Wysocki, Sylwia Kołtan, Violetta Swiatkiewicz, Andrzej Kołtan, Anna Balcar-BorońMed Sci Monit 2002; 8(4): CR274-279 :: ID: 420868
Abstract
BACKGROUND: Viral hepatitis C in children is milder than in adults. Patientswith tumors, because of immune deficits, seem to be at risk of rapid liver disease progression. Littleis known about the course of HCV and dual HBV-HCV infections in such patients. MATERIAL/METHODS: Thestudy assessed clinical courses of HCV and dual HBV-HCV infections in 249 children with tumors aged 1-18years, divided into four groups: with HCV infection - 53, HBV-HCV infection - 53, HBV only - 33 and infection-free- 110. RESULTS: Hepatitis C was often chronic - in 83.3% of patients with HCV and 77.3% of those withdual infection. Over 80% had no jaundice. Mean AlAT activity was the highest in the HCV group (149.2I202.7IU/l), lower in the dual infection group (123.3I148.1 IU/l; p<0.02), and the lowest in HBV (92.7±152.9 IU/l). Transaminasemia course in patients with HCV and dual HBV-HCV infections was most frequently fluctuating (50.9% and 45.3%, respectively). 52.8% of children with HCV demonstrated no advanced inflammatory lesions with invasion of the
lamina limitans, no marked fibrosis, and minimum changes in descriptive classification. In 92.3% of children with dual infections, inflammatory activity was mild or mean, with no fibrosis
in 61.5%, and persistent chronic inflammation predominant in descriptive classification(46.1%).
Conclusions: HCV and HBV-HCV infections in children with neoplastic diseases tend to take chronic forms, but their clinical course is mild with signs of severe inflammatory activity or hepatic
stroma remodeling observed on histopathology.
Keywords: Adolescent, Alanine Transaminase, bilirubin, Biopsy, Child, Child, Preschool, Comparative Study, Disease Progression, Follow-Up Studies, Hepatitis B, Hepatitis B, Chronic, Hepatitis C, Hepatitis C, Chronic, Incidence, Leukemia, Liver, Liver Cirrhosis, Neoplasms, Severity of Illness Index
Editorial
01 March 2024 : Editorial
Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-ThalassemiaDOI: 10.12659/MSM.944204
Med Sci Monit 2024; 30:e944204
In Press
18 Mar 2024 : Clinical Research
Sexual Dysfunction in Women After Tibial Fracture: A Retrospective Comparative StudyMed Sci Monit In Press; DOI: 10.12659/MSM.944136
21 Feb 2024 : Clinical Research
Potential Value of HSP90α in Prognosis of Triple-Negative Breast CancerMed Sci Monit In Press; DOI: 10.12659/MSM.943049
22 Feb 2024 : Review article
Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...Med Sci Monit In Press; DOI: 10.12659/MSM.943168
23 Feb 2024 : Clinical Research
A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...Med Sci Monit In Press; DOI: 10.12659/MSM.943732
Most Viewed Current Articles
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952