15 May 2002
Lack of association of G-protein subunit gene C825T polymorphism with leftventricular hypertrophy in essential hypertension.
Eugene I Shwartz, Yulia B Nefedova, Anna V Zukova, Eugene V Shlyakhto, Tatyana A Vinnic, Alexandra O KonradyMed Sci Monit 2002; 8(5): CR337-340 :: ID: 420839
Abstract
BACKGROUND: The aim of the present study was to determine if there is anassociation of G-protein b3 subunit (GNB3) gene polymorphisms and left ventricular hypertrophy (LVH)in patients with essential hypertension (EH) in a St. Petersburg population. MATERIAL/METHODS: We examined135 patients (mean age 48 +/- 7 yrs) with mild to moderate EH recruited from the general population ofan outpatient hypertension clinic. Left ventricular mass was measured by echocardiography, and the leftventricular mass index (LVMI) was calculated. The GNB3 C825T genotype was determined by polymerase chainreaction and restriction digestion. RESULTS: 67 patients (50%) were homozygous for the C allele (CC),56 were heterozygous (CT) (41%) and twelve (9%) were homozygous for the T allele (TT). The distributionof genotypes among the patients was in Hardy-Weinberg equilibrium and did not differ significantly whencomparing patients with or without LVH. The frequency of the T allele was only slightly higher in patientswith LVH (32%) compared to those without LVH (28%), NS, and the LVMI was similar in patients with theCC, CT and TT genotypes (122.3 +/- 29.8; 118.8 +/- 29.9 and 115.2 +/- 18.3 g/m2, respectively). No significantdiscrepancies were found among the various genotype groups in posterior wall thickness, interventricularseptum thickness, or functional parameters such as ejection fraction, isovolumetric relaxation time andE/A ratio. CONCLUSIONS: These observations clearly suggest the lack of association between left ventricularstructure or function and the CNB3 gene variant in the studied population.
Keywords: Alleles, DNA Restriction Enzymes, Echocardiography, Genotype, Heterotrimeric GTP-Binding Proteins, Homozygote, Hypertension, Hypertrophy, Left Ventricular, Polymerase Chain Reaction, Polymorphism, Genetic
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
08 Mar 2024 : Clinical Research
Evaluation of Foot Structure in Preschool Children Based on Body MassMed Sci Monit In Press; DOI: 10.12659/MSM.943765
15 Apr 2024 : Laboratory Research
The Role of Copper-Induced M2 Macrophage Polarization in Protecting Cartilage Matrix in OsteoarthritisMed Sci Monit In Press; DOI: 10.12659/MSM.943738
07 Mar 2024 : Clinical Research
Knowledge of and Attitudes Toward Clinical Trials: A Questionnaire-Based Study of 179 Male Third- and Fourt...Med Sci Monit In Press; DOI: 10.12659/MSM.943468
08 Mar 2024 : Animal Research
Modification of Experimental Model of Necrotizing Enterocolitis (NEC) in Rat Pups by Single Exposure to Hyp...Med Sci Monit In Press; DOI: 10.12659/MSM.943443
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952