02 July 2004
Thyroid cancer has increased in the adult populations of countries moderately affected by Chernobyl fallout
Stefan Murbeth, Milena Rousarova, Hagen Scherb, Edmund LengfelderMed Sci Monit 2004; 10(7): CR300-306 :: ID: 11703
Abstract
Background:The incidence of thyroid carcinoma increased among children affected by Chernobyl fallout. Less evidence exists for a corresponding effect in adolescents and adults. The Cancer Registry of the Czech Republic provides an opportunity to study various determinants of the occurrence of thyroid cancer.Material/Methods:Anonymous population-based incidence data on thyroid carcinoma of the Czech Republic from 1976 to 1999 were obtained from the Czech Statistical Office (CSO) and the Institute of Health Information and Statistics (IHIS). This study covers 247 million person-years. Linear logistic regression models allowing for possible changes in slope (change-points) are suggested for the trends of incidence proportions.Results:From 1976 to 1999 a uniform annual increase of 2.0% per year was found in the directly age-standardized thyroid cancer incidence proportion (95%-CI: 1.3−2.7, p<0.0001). From 1990 on, we observed an additional significant increase in the thyroid cancer incidence of 2.6% per year (95%-CI: 1.2-4.1, p=0.0003). This effect (change-point) is essentially independent of age but dependent on gender: females 2.9% per year (95%-CI: 1.3-4.7, p=0.0006), males 1.8% per year (95%-CI: –1.0-4.7, p=0.2127). The estimated minimum latency period for the population as a whole is 4 years.
Conclusions: Although the Czech Republic received only a relatively moderate amount of radioactive fallout, an unexpected uniformly accelerated increase of thyroid cancer in all age categories is seen from 1990 onwards. Therefore one should look carefully at collective dose and at the group of persons low in individual organ dose but high in number.
Keywords: Adolescent, Child, Child, Preschool, Czech Republic - epidemiology, Incidence, Infant, Newborn, Linear Models, Logistic Models, Neoplasms, Radiation-Induced - epidemiology, Neoplasms, Radiation-Induced - etiology, Population Surveillance, Radioactive Fallout - adverse effects, Thyroid Neoplasms - epidemiology, Thyroid Neoplasms - etiology, Ukraine - epidemiology, Adolescent, Child, Child, Preschool, Czech Republic - epidemiology, Incidence, Infant, Newborn, Linear Models, Logistic Models, Neoplasms, Radiation-Induced - etiology, Population Surveillance, Radioactive Fallout - adverse effects, Thyroid Neoplasms - etiology, Ukraine - epidemiology
Editorial
01 March 2024 : Editorial
Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-ThalassemiaDOI: 10.12659/MSM.944204
Med Sci Monit 2024; 30:e944204
In Press
18 Mar 2024 : Clinical Research
Sexual Dysfunction in Women After Tibial Fracture: A Retrospective Comparative StudyMed Sci Monit In Press; DOI: 10.12659/MSM.944136
21 Feb 2024 : Clinical Research
Potential Value of HSP90α in Prognosis of Triple-Negative Breast CancerMed Sci Monit In Press; DOI: 10.12659/MSM.943049
22 Feb 2024 : Review article
Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...Med Sci Monit In Press; DOI: 10.12659/MSM.943168
23 Feb 2024 : Clinical Research
A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...Med Sci Monit In Press; DOI: 10.12659/MSM.943732
Most Viewed Current Articles
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952