25 July 2022>: Database Analysis
Integrating Network Pharmacology, Molecular Docking, and Experimental Validation to Investigate the Mechanism of (−)-Guaiol Against Lung Adenocarcinoma
Yaoying Zeng 1E* , Yanbin Pan 1B* , Bo Zhang 1C , Yingbin Luo 1D , Jianhui Tian 1AF , Yuli Wang 1CD , Xudong Ju 2BF , Jianchun Wu 1A* , Yan Li 1A*DOI: 10.12659/MSM.937131
Med Sci Monit 2022; 28:e937131
Figure 9 (A) Flow cytometry to detect the apoptosis rate in A549 and Calu-1 treated with different concentrations of (−)-Guaiol. (B) Fluorescence microscope was used to observe apoptosis in A549 and Calu-1 treated with different concentrations of (−)-Guaiol. (C) Western blot analysis was used to detect the protein expression of BAX and Bcl-2 in A549 treated with (−)-Guaiol (60 μM or 120 μM). The relative BAX and Bcl-2 levels from 3 independent experiments were statistically analyzed using ANOV A test in the quantitative analysis. * P<0.05, *** P<0.001 vs control.